BRIDGING THE GAP: A CASE STUDY AND COMPREHENSIVE REVIEW OF PULMONARY BLASTOMA

• Prof. Benjamin Carter

  Division Of Thoracic Surgery, Mayo Clinic, Rochester, Minnesota, Usa

  Author

• Dr. Chen Wei

  Department Of Pathology, Shanghai Jiao Tong University School Of Medicine, Shanghai, China

  Author

Pulmonary blastoma (PB) is an extraordinarily rare and aggressive form of lung cancer, distinguished by its unique blend of primitive mesenchymal and fetal-like epithelial cells. Since its initial documentation in the mid-20th century, this tumor has continued to present significant hurdles in diagnosis and treatment, largely due to its scarcity, diverse clinical presentations, and intricate pathological features. This comprehensive article delves into the journey of an adult patient diagnosed with classic biphasic pulmonary blastoma, offering a detailed account of their clinical experience, diagnostic investigations, and the subsequent treatment path. Alongside this personal narrative, we provide a thorough review of the current scientific understanding, exploring its historical roots, evolving classifications, how it affects different populations, its varied symptoms, advanced diagnostic tools like imaging and immunohistochemistry, and the range of treatment options available, from surgery to chemotherapy and promising new molecular therapies. Furthermore, this review critically examines the factors that influence patient outcomes and underscores the vital need for collaborative research to establish clear, standardized care guidelines. By bringing together existing knowledge and a contemporary case study, this article aims to deepen our collective understanding of PB, promote earlier and more accurate diagnoses, and ultimately contribute to more effective treatments and improved lives for those facing this challenging cancer.

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