SOX3 REGULATES GRANULOSA CELL DYNAMICS: MODULATION OF PI3K/AKT PATHWAY THROUGH SPP1 TARGETING
Keywords:
SOX3, granulosa cells, proliferation, apoptosisAbstract
Ovarian granulosa cells (GCs) are crucial for female fertility, with their proliferation and apoptosis precisely regulated. Dysregulation of these processes contributes to ovarian disorders. This study investigates the role of the transcription factor SOX3 in granulosa cell dynamics and its underlying molecular mechanisms. We demonstrate that SOX3 promotes GC proliferation and suppresses apoptosis. Mechanistically, SOX3 achieves these effects by directly upregulating the expression of Secreted Phosphoprotein 1 (SPP1), which subsequently activates the Phosphoinositide 3-kinase/protein kinase B (PI3K/AKT) signaling pathway. Our findings establish a novel SOX3-SPP1-PI3K/AKT axis as a critical regulatory mechanism in granulosa cell function, offering potential targets for therapeutic interventions in reproductive health.
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