A FATAL CASE OF PNEUMOCEPHALUS LINKED TO HYPERMUCOVISCOUS, HYPRECLINICAL SAFETY ASSESSMENT OF EUPHORBIA HIRTA EXTRACTS: ACUTE AND SUBACUTE TOXICITY IN RODENT MODELS

Dr. Kembah A. Rodalle; Dr. Melvia N. Ikrawan; Dr. Tharun J. Belmika

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A FATAL CASE OF PNEUMOCEPHALUS LINKED TO HYPERMUCOVISCOUS, HYPRECLINICAL SAFETY ASSESSMENT OF EUPHORBIA HIRTA EXTRACTS: ACUTE AND SUBACUTE TOXICITY IN RODENT MODELS

Dr. Kembah A. Rodalle ¹ , Dr. Melvia N. Ikrawan ² , Dr. Tharun J. Belmika ³

¹ Department of Pharmacology and Toxicology, Institute of Biomedical Sciences, University of Dodoma, Tanzania

² Center for Natural Product Research, Faculty of Pharmacy, Universiti Teknologi Sarawak, Malaysia

³ Division of Toxicological Studies, Indian Institute of Experimental Medicine, Bhubaneswar, Odisha, India

Issue Vol. 1 No. 01 (2024): Volume 01 Issue 01 --- Section Articles --- Published Date: 2024-12-20

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Abstract

Euphorbia hirta, a widely used medicinal plant, holds significant traditional and pharmacological importance. This study aimed to evaluate the acute and subacute oral toxicity of Euphorbia hirta methanol extract in mice and Wistar rats, respectively. In the acute toxicity study, single oral doses up to 5000 mg/kg in mice caused no mortality or significant clinical signs, indicating a low acute toxicity profile (LD50 > 5000 mg/kg). For the subacute study, Wistar rats received daily oral doses of 250, 500, or 1000 mg/kg for 28 days. No significant changes were observed in body weight, organ weights, food/water intake, hematological parameters (RBC, WBC, Hb, PCV, platelets), or biochemical markers of liver (ALT, AST, ALP) and kidney (creatinine, urea) function across all treated groups compared to controls. Histopathological examination of vital organs (liver, kidneys, spleen, heart, lungs, brain) also revealed no morphological alterations. These findings suggest that Euphorbia hirta methanol extract has a favorable safety profile with no significant systemic or organ-specific toxicity at the tested doses, supporting its traditional use and potential for therapeutic development.

Keywords

Euphorbia hirta, acute toxicity, subacute toxicity, preclinical safety

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How to Cite

Dr. Kembah A. Rodalle, Dr. Melvia N. Ikrawan, & Dr. Tharun J. Belmika. (2024). A FATAL CASE OF PNEUMOCEPHALUS LINKED TO HYPERMUCOVISCOUS, HYPRECLINICAL SAFETY ASSESSMENT OF EUPHORBIA HIRTA EXTRACTS: ACUTE AND SUBACUTE TOXICITY IN RODENT MODELS. European Frontiers in Current Science and Research, 1(01), 41-52. https://parthenonfrontiers.com/index.php/efcsr/article/view/171

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A FATAL CASE OF PNEUMOCEPHALUS LINKED TO HYPERMUCOVISCOUS, HYPRECLINICAL SAFETY ASSESSMENT OF EUPHORBIA HIRTA EXTRACTS: ACUTE AND SUBACUTE TOXICITY IN RODENT MODELS

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